Jun 16, 2025
The combination of epirubicin, cisplatin, and 5-fluorouracil (ECF) is widely used for gastric cancer treatment. However, cancer cells can acquire chemoresistance over multiple treatment cycles, leading to recurrence. This study...
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Mesenchymal Stromal Cells (MSC)-derived Extracellular Vesicles (EV) represent innovative tools for drug delivery systems. However, their clinical use is limited by the lack of standardized good manufacturing practice...
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Recessive mutations in POLR3A exhibit considerable phenotypic diversity, spanning from severe childhood-onset hypomyelinating leukodystrophic syndrome to less severe gait disorders, which may present later in life and may be...
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Unexpected pregnancy loss can be a traumatic experience for fertile couples. The aim of the study was to assess the nature and type of chromosomal variants involved in early and late pregnancy loss and provide couples an...
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Female cancer survivors often experience sexual dysfunction, which is a significant and increasingly recognized aspect of survivorship. This review compares guidelines from the American Society of Clinical Oncology (ASCO), the...
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The development of anxiety during protracted opioid withdrawal heightens the risk of relapse into the cycle of addiction. Understanding the mechanisms driving anxiety during opioid withdrawal could facilitate the development of...
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Three decades have passed since the initial approval of disease-modifying therapies (DMTs). Ongoing discussion is focused on fundamental aspects of the disease, highlighting a growing division between successes in managing...
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Dysregulation of the endocannabinoid system (ECS) might be related to autism spectrum disorder (ASD). This study conducts a meta-analysis on the dysregulation of the ECS across ASD animal models and individuals with ASD and...
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The human gut microbiota performs a variety of essential physiological homeostasis functions, including the development of the immune system, nutrient synthesis, vitamin production, and energy metabolism. Ginger’s...
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Hemodialysis is a lifesaving therapy but imposes a significant environmental burden due to its excessive consumption of water and energy and the generation of non-recyclable medical waste. The emerging Green Dialysis movement...
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This study assesses international travelers’ risk perceptions and travel decisions related to three recent emerging diseases. Travelers can facilitate the spread of emerging infectious diseases and their decision-making on...
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Pancreatic cancer (PC) has a strong ability to invade and metastasize, which has brought insurmountable obstacles to the treatment of PC. Exploring the molecular mechanism of PC metastasis is still the focus of PC research. The...
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The declining efficacy and widespread resistance to antimalarial drugs (AMD) pose significant challenges to global malaria control and elimination efforts. To enhance treatment efficacy, the World Health Organization (WHO)...
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To evaluate tumour necrosis factor inhibitor (TNFi) usage patterns in pregnant women with rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis (PsA), psoriasis (PsO), and inflammatory bowel diseases (IBD),...
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Colorectal cancer (CRC) remains a significant health challenge globally, demanding a comprehensive understanding of its molecular underpinnings for effective management. In this study, we investigated the role of Aldolase C...
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The objective of this study was to establish a comparison between the vessel density (VD) and foveal avascular zone (FAZ) of patients with type 2 diabetes mellitus (T2DM) who lacked clinical signs of diabetic retinopathy (DR)...
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Cortical laminar necrosis (CLN) is a selective cortical necrosis primarily involving layer 3 of the cortex. Its causes, clinical features, and outcomes in pediatric patients remain unclear due to limited cases.Pediatric CLN...
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Calciphylaxis, also termed calcific uremic arteriolopathy (CUA) in patients with end-stage kidney disease (ESKD), is a rare and fatal condition characterized by cutaneous ischemic necrosis.Three patients with calciphylaxis and...
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To explore the neuroprotective role of Myeloid-Derived Growth Factor (MYDGF) and its regulatory mechanisms involving G protein-coupled signaling pathways after cerebral ischemia-reperfusion injury (CIRI).A mouse model of CIRI...
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IntroductionColorectal cancer (CRC) is the third most common cancer worldwide, with higher rates in industrialized countries. By 2030, the number of CRC cases may rise by 60%, reaching 2.2 million new cases and 1.1 million...
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