Jun 16, 2025
Epilepsy is a long-lasting neurological condition distinguished by recurring seizures, and related to oxidative stress and inflammation. This study investigates the effects of long non-coding RNA LBX2-AS1 on childhood...
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To evaluate modifiable lifestyle-genetic susceptibility interaction with the risk of ankylosing spondylitis (AS).This study included 382,035 individuals free of AS at baseline in the UK Biobank. A combined lifestyle score...
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Obstructive sleep apnea (OSA), a serious sleep disorder, can lead to comorbidities and decreased quality of life if untreated. Poor sleep quality from OSA affects concentration, cognitive function, and mental health,...
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Lactate plays a central role in controlling the utilization of energy substrates and the selection of metabolic pathways. This review aims to determine how lactate participates in energy supply and elaborate on how lactate is...
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The demethylase fat mass and obesity-related associated protein (FTO) is strongly associated with depression. Aging is a risk factor for synaptic plasticity damage in the brain and leads to neurocognitive dysfunctions....
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Bleeding represents a critical challenge across diverse medical scenarios, underscoring the urgent need for the development of advanced hemostatic materials. This review focuses on gelatin-based hemostatic hydrogels, which exert...
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To evaluate long-term outcomes of anti-VEGF therapy for neovascular age-related macular degeneration (nAMD) in the Netherlands (NL), where bevacizumab is the mandated first-line drug, compared to high-income countries using...
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To provide a comprehensive and internationally standardised Cornea and Ocular Surface Disease (C&OSD) dataset for use in electronic health records (EHRs).This was an international consensus study conducted through roundtable...
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Dose escalation has demonstrated a significant improvement in biochemical recurrence in high-risk prostate cancer (HRPCa). We evaluated the impact on overall survival (OS) of dose intensification with external beam radiation...
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The combination of epirubicin, cisplatin, and 5-fluorouracil (ECF) is widely used for gastric cancer treatment. However, cancer cells can acquire chemoresistance over multiple treatment cycles, leading to recurrence. This study...
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Mesenchymal Stromal Cells (MSC)-derived Extracellular Vesicles (EV) represent innovative tools for drug delivery systems. However, their clinical use is limited by the lack of standardized good manufacturing practice...
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Recessive mutations in POLR3A exhibit considerable phenotypic diversity, spanning from severe childhood-onset hypomyelinating leukodystrophic syndrome to less severe gait disorders, which may present later in life and may be...
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Unexpected pregnancy loss can be a traumatic experience for fertile couples. The aim of the study was to assess the nature and type of chromosomal variants involved in early and late pregnancy loss and provide couples an...
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Female cancer survivors often experience sexual dysfunction, which is a significant and increasingly recognized aspect of survivorship. This review compares guidelines from the American Society of Clinical Oncology (ASCO), the...
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The development of anxiety during protracted opioid withdrawal heightens the risk of relapse into the cycle of addiction. Understanding the mechanisms driving anxiety during opioid withdrawal could facilitate the development of...
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Three decades have passed since the initial approval of disease-modifying therapies (DMTs). Ongoing discussion is focused on fundamental aspects of the disease, highlighting a growing division between successes in managing...
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Dysregulation of the endocannabinoid system (ECS) might be related to autism spectrum disorder (ASD). This study conducts a meta-analysis on the dysregulation of the ECS across ASD animal models and individuals with ASD and...
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The human gut microbiota performs a variety of essential physiological homeostasis functions, including the development of the immune system, nutrient synthesis, vitamin production, and energy metabolism. Ginger’s...
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Hemodialysis is a lifesaving therapy but imposes a significant environmental burden due to its excessive consumption of water and energy and the generation of non-recyclable medical waste. The emerging Green Dialysis movement...
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This study assesses international travelers’ risk perceptions and travel decisions related to three recent emerging diseases. Travelers can facilitate the spread of emerging infectious diseases and their decision-making on...
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